The top three teams in the Premier League have all lost, and a repeat of last season’s title triumph looks unlikely.
But the Blues could make history by securing a second consecutive Premier League title with a victory at Stamford Bridge, which will see them win for the third time in the past four seasons.
The home side will be hoping to get back into the Champions League for the first time since their run of four successive domestic triumphs ended with a 3-1 defeat at Manchester United in the 2013/14 campaign.
That season saw Chelsea win four and draw one of their five league games, which included a 1-0 victory over the Red Devils in the FA Cup final.
But this season’s run ended with the champions missing out on the Champions league spot, finishing with just two points from a possible 11.
The Blues are back in the top flight for the second time in four years, with a new season under their belt.
This year is set to be different, with the title race increasingly competitive with Manchester City, Chelsea and Liverpool all challenging for the title.
Chelsea are currently third, two points clear of Manchester United and four behind Manchester City.
However, City will be looking to secure the title as they try to win back the Champions, who beat them in the first leg of the Champions Cup last season.
Manchester City will face Chelsea at Stamford Park in the second leg of their Champions League quarter-final on Sunday (kick-off 17:00 GMT)After that game, the Blues will face the Red Bull Salzburg in the semi-final.
Both clubs will play on Saturday, when the tie will kick off at 20:00 (GMT).